It is definitely difficult to be home-bound and coping with a number of medical problems and physical disabilities. I can understand why you would feel both lonely and frustrated. It is easy to start feeling down and stop trying to reach out to others. I think the first thing to do is to let the people that you trust (like your children or friends or folks who live near you) know that you want to have more contact with people. It's hard to let people know you feel distant from them, but they are often happy to help and find ways to reach out when they realize that you are struggling. They might have ideas of ways to increase your contact with others, such as helping you get to a Senior center, finding a friendly visitor program, or connecting you with neighbors or others in your building (if you are in an apartment) who are also searching for someone new to talk to. Another option you may consider is calling Institute on Aging's free Friendship Line. The Friendship Line's trained staff and volunteers offer an ongoing connection for depressed or lonely older adults who are in situations similar to yours. To reach the Friendship Line, simply call (415) 752-3778 or call toll free: (800) 971-0016. You may also want to consider making use of IOA's in-home psychotherapy services. We regularly work with individuals' in their homes and find that individual therapy can help you to address feeling down and help you find better ways to cope. Most services are covered by Medicare. If you are interested in individual therapy at home, simply call: 415-750-4111.